Lactate Dehydrogenase A anticorps (AA 1-332)

N° du produit ABIN7596077

Cet anticorps anti-Lactate Dehydrogenase A est un anticorps Souris Monoclonal détectant Lactate Dehydrogenase A dans WB, ELISA, IF et ICC. Adapté pour Humain.

Aperçu rapide pour Lactate Dehydrogenase A anticorps (AA 1-332) (ABIN7596077)

Antigène: Lactate Dehydrogenase A (LDHA)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Lactate Dehydrogenase A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AT1A4

Détail du produit anti-Lactate Dehydrogenase A anticorps

Épitope: AA 1-332

Fonction: Human Lactate Dehydrogenase A/LDHA antibody

Purification: protein-A affinity chromatography

Immunogène: Recombinant human LDHA (1-332aa) purified from E.coli

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Détails sur Lactate Dehydrogenase A

Antigène: Lactate Dehydrogenase A (LDHA)

Autre désignation: Lactate Dehydrogenase A/LDHA

Sujet: Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.

NCBI Accession: NP_005557

Pathways: L'effet Warburg